Radioimmunoscintigraphy of ocular melanoma with 99mTc labelled cutaneous melanoma antibody fragments.
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منابع مشابه
Radioimmunoscintigraphy of ocular melanoma with 99mTc labelled cutaneous melanoma antibody fragments.
The possibility of using radiolabelled monoclonal antibody fragments to image uveal melanomas has been assessed in a pilot study. 99mTc labelled F(ab')2 fragments of MoAb 225.28S raised against cutaneous melanomas were used. Initially 10 patients were imaged. In five patients the clinical findings were typical of uveal melanoma. Immunoscintigraphy was positive in all five cases. In a further fi...
متن کاملCharacterisation of ocular melanoma with cutaneous melanoma antibodies.
It can be difficult to distinguish between various forms of pale intraocular tumour, and in particular between an amelanotic malignant melanoma, a choroidal haemangioma, and a solitary metastasis. If a monoclonal antibody specific for melanoma could be identified, it might be radiolabelled to provide a scanning technique which could distinguish between an ocular melanoma and a similar lesion. T...
متن کاملGermline BAP1 Inactivation Is Preferentially Associated with Metastatic Ocular Melanoma and Cutaneous-Ocular Melanoma Families
BACKGROUND BAP1 has been shown to be a target of both somatic alteration in high-risk ocular melanomas (OM) and germline inactivation in a few individuals from cancer-prone families. These findings suggest that constitutional BAP1 changes may predispose individuals to metastatic OM and that familial permeation of deleterious alleles could delineate a new cancer syndrome. DESIGN To characteriz...
متن کاملTumor Imaging with 99mTc-Labelled Antibody Fragmentst
Althoughthe labelling of proteins with was established in 1964 by McAfee, et al., this isotope has been avoided by most investigators for the labelling of antibodies for tumor localization. There are several reasons for this: (1)the half-life is only 6 hours while most previous radiolabelled antibody localization studies have shown that the required tumor-toblood ratio needed for tumor visualiz...
متن کاملOcular melanoma.
The eye is the second most common site for primary melanoma after the skin. An ophthalmologic evaluation should be an integral aspect of melanoma screening that is often not even considered by nonophthalmologists. Delays or failures to make an accurate and early diagnosis can have grave consequences. Early recognition and diagnosis, before the tumor has progressed into an advanced process with ...
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ژورنال
عنوان ژورنال: British Journal of Ophthalmology
سال: 1987
ISSN: 0007-1161
DOI: 10.1136/bjo.71.9.651